Meeting Banner
Abstract #1307

Beyond Brain Age: QS-GAP as a Quantile-Based Tool for Detecting Neurodegenerative Aging Patterns

Rafael Navarro-Gonzalez1, Rodrigo de Luis-Garcia1, and Santiago Aja-Fernández1
1Universidad de Valladolid, Valladolid, Spain

Synopsis

Keywords: Diagnosis/Prediction, Neurodegeneration, Brain Age

Motivation: The need for precise brain age estimation has grown, especially in differentiating typical from atypical aging patterns in Alzheimer's disease (AD) research.

Goal(s): We propose, Quantile-SHAP Gap in Aging Patterns (QS-GAP), which aims to enhance brain aging prediction by using machine learning on MRI data, creating assessments that align with cohort norms.

Approach: QS-GAP estimates brain age through quantile-based predictions, using the closest quantile to a person’s actual age as a baseline and median quantile for general aging. SHAP values for controls create a reference aging pattern.

Results: QS-GAP’s quantile-based method slightly outperformed raw features in classifying AD versus cognitively normal (CN) individuals.

Impact: QS-GAP offers a refined, personalized approach to assessing brain aging, enhancing classification between AD and CN individuals. By aligning aging patterns with cohort norms, it supports more accurate diagnostics and advances neurodegenerative research, particularly in individualized brain health assessments.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords