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Abstract #1333

Prostate Diffusion-Weighted Imaging with an Inside-Out Nonlinear Gradient Coil

Horace Z. Zhang1, Nahla M. H. Elsaid2, Jeffery C. Weinreb2, and Gigi Galiana1,2
1Department of Biomedical Engineering, Yale University, New Haven, CT, United States, 2Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

Synopsis

Keywords: Gradients, Gradients, Prostate, SNR, CNR

Motivation: Widely used to diagnose prostate cancer, diffusion-weighted imaging (DWI) is limited by gradient strength. As an alternative to costly whole-body strong-gradient scanners, we proposed an insertable inside-out nonlinear gradient coil tailored for the prostate.

Goal(s): Achieve the required diffusion weighting in the prostate with high signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).

Approach: We developed DWI methods for the nonlinear gradient, including eddy current correction and design of diffusion encoding scheme.

Results: The nonlinear gradient reduces echo time (42ms vs. 57ms or 72ms), enhances prostate SNR, and shows promise for high lesion CNR.

Impact: The proposed inside-out nonlinear gradient coil provides easy access to strong gradient for high-SNR and high-CNR prostate DWI, which can be flexibly installed for clinical scanners and facilitates triage, diagnosis, and surveillance of prostate cancer.

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Keywords