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Abstract #1345

Intra- and inter-regional neural activity synchronizations drive rsfMRI network dynamics upon single thalamic input

Linshan Xie1,2, Xunda Wang1,2, Xuehong Lin1,2, Junjian Wen1,2, Alex T. L. Leong1,2, and Ed X. Wu1,2,3
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 3School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

Synopsis

Keywords: Task/Intervention Based fMRI, Multimodal, fMRI (resting-state), functional connectivity, neuroscience

Motivation: Understanding large-scale network dynamics that facilitate neural information processing can unravel the complexities of brain networks and their functions.

Goal(s): We posit that dissecting neural underpinnings of rsfMRI dynamics and their reconfiguration upon neural activity input will provide a mechanistic understanding of how brain networks support information processing.

Approach: We deployed simultaneous electrophysiology-rsfMRI measurements to examine neural bases underlying rsfMRI network dynamics before and upon single-pulse optogenetic stimulation of the thalamus.

Results: We revealed that the rsfMRI network dynamics and their instant reconfigurations were directly driven by distinct within- and between-network neural activity synchronizations across specific time and frequency windows.

Impact: Our results provide the first direct delineation and validation of rsfMRI network dynamics that enable prompt and flexible network reconfiguration to facilitate effective processing of any neural information input.

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Keywords