Abstract #1349

Brain-wide spatiotemporally distinct traveling waves drive anxiety-like behaviors in mice

Jiaming Liu¹, Jia-Wen Mo², Xunda Wang³, Yinuo Ma⁴, Peng-Li Kong², Ziqi An⁴, Li Ding², Jing Ren², Cheng-Lin Lu², Chuanjun Tong⁵, Ed X. Wu⁶, Qiu-gen Hu¹, Xiong Cao¹, and Yanqiu Feng^1,2,4

¹Department of Radiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China, ²Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China, ³Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, California, CA, United States, ⁴School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, ⁵Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China, ⁶Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

Synopsis

Keywords: Task/Intervention Based fMRI, Neuroscience, Traveling waves; Anxiety; Cortical spreading depression

Motivation: Even though traveling waves coordinate neural communication to modulate brain function and dysfunction, their propagation dynamics and functional roles remain unclear.

Goal(s): We investigate brain-wide spatiotemporal propagation properties of traveling waves and their effects on behaviors.

Approach: Using optogenetics alongside fMRI in mice.

Results: We demenstrated that optogenetic activation induces cortical spreading depression (CSD)-like traveling waves. These waves propagate beyond the ipsilateral cortex to subcortical structures along cortico-amygdalar-striatal pathways, ultimately terminating in striatum. Propagation directions, speed, duration, and region involvement vary with origins. CSD-like waves induce anxiety-like behaviors by increasing dendritic spine density.

Impact: Our study provide brain-wide view of the traveling wave propagation and reveals their functional role in inducing anxiety.

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