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Abstract #1355

Quantitative assessment of cardiac oxidative metabolism under physiological and pharmacological stress using CEST imaging and MRS

Qi Huang1, Caleb Berberet1, Cihat Eldeniz1, Ryan Wahidi1, Linda R. Peterson1, Thomas H. Schindler1, Pamela Woodard1, and Jie Zheng1
1Washington University in St. Louis, St. Louis, MO, United States

Synopsis

Keywords: CEST / APT / NOE, CEST & MT, MRS, Exercise

Motivation: Assessing changes of the cardiac phosphocreatine (PCr) at rest and stress may be a valuable biomarker to cardiometabolic health.

Goal(s): To test the feasibility of quantifying changes of PCr concentrations in vivo.

Approach: Evaluating feasibility of the cardiac CEST imaging in a canine study with vasodilation. Applying CMR CEST and 31P MR spectroscopy in human subjects and comparing PCr quantification at rest and during exercise.

Results: The results of the dog study indicated that myocardial PCr concentrations were conserved during vasodilation. The rest-exercise-recovery imaging session in human experiments demonstrated reduced PCr concentrations during exercise.

Impact: The feasibility of tracking PCr changes in different physiological states is critical for the diagnosis of heart tissue dysfunction. The validation of MRS consolidates the accuracy of the CEST results.

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