Abstract #1358

3T vs 7T CEST contrast comparison in a prospective diagnostic study in glioma patients: insights into age dependence and tumor subtype sensitivity

Milena Capiglioni^1,2, Moritz Simon Fabian³, Richard McKinley¹, Roland Wiest^1,2, Moritz Zaiss^3,4, Robert Hoeppner⁵, Johannes Slotboom^1,2, and Piotr Radojewski^1,2

¹Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, ²Translational Imaging Center (TIC), Sitem-insel, Bern, Switzerland, ³Institute of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Department of Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁵Department of Neurology, Inselspital, University of Bern, Bern, Switzerland

Synopsis

Keywords: CEST / APT / NOE, Tumors, Neurodegeneration, Biomarkers, Data Analysis, High-Field MRI

Motivation: Chemical exchange saturation transfer (CEST) is a metabolic imaging tool increasingly used in glioma research. While 7T CEST offers superior chemical shift separation and SNR, 3T remains the clinical standard. Comparing these strengths can clarify CEST’s diagnostic potential.

Goal(s): To compare CEST contrasts at 3T vs. 7T in a glioma cohort, focusing on age dependence and tumor subtype sensitivity.

Approach: We scanned 43 glioma patients at both 3T and 7T, analyzing CEST pools’ Lorentzian amplitudes in normally appearing and tumor tissues.

Results: Stronger age dependence appeared at 7T in normally appearing tissue, and not in tumor; IDH mutation sensitivity remains inconclusive across fields.

Impact: This study shows that 7T CEST enhances age-dependent contrast but offers limited advantage for tumor subtyping over 3T, elucidating CEST’s diagnostic potential. Future research can use age-related CEST changes at 7T to differentiate normal from pathological aging in clinical neuroimaging.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.