Abstract #1360

Fat-corrected rNOE-CEST contrast for breast cancer imaging

Petr Menshchikov¹, Philip S. Boyd¹, Lisa Loi^2,3, Neele Kempa^1,4, Mark E. Ladd^1,3,4, Heinz-Peter Schlemmer^2,3, Peter Bachert^1,4, Daniel Paech^2,3, and Andreas Korzowski¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, ⁴Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE

Motivation: Application of quantitative CEST contrasts for breast imaging is limited due to pronounced fat-induced artifacts. The most prominent fat artifact appears in the Z-spectrum between [-2,-4] ppm, directly overlapping the rNOE signal at around -3.5 ppm, making accurate rNOE evaluation extremely challenging.

Goal(s): To investigate fat-corrected rNOE-CEST contrast (MTR_Rex) in breast cancer.

Approach: We retrospectively apply a novel postprocessing fat correction procedure on CEST data of patients with breast cancer.

Results: Fat-corrected MTR_Rex rNOE values showed 140% increase in tumor as compared to normal-appearing glandular tissue. Furthermore, a strong correlation (R²=0.71) between MTR_Rex rNOE and the tumor proliferation marker Ki-67 was found.

Impact: The significant elevation in fat-corrected MTRRex rNOE contrast along with the strong correlation with a tumor proliferation marker indicate the potential to use rNOE imaging as a valuable non-invasive imaging biomarker for breast cancer diagnosis, treatment planning, and monitoring.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.