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Abstract #1369

Controlling sharpness, SNR and SAR for 3D fast spin echo measurements at 7T by end-to-end learning

Peter Dawood1,2, Martin Blaimer3, Jürgen Herrler4, Patrick Liebig4, Simon Weinmüller1, Shaihan Malik5, Peter M. Jakob2, and Moritz Zaiss1,6
1Institute of Neuroradiology, University Hospital Erlangen, Erlangen, Germany, 2Experimental Physics 5, University of Würzburg, Würzburg, Germany, 3Magnetic Resonance and X-ray Imaging Department, Fraunhofer Institute for Integrated Circuits IIS, Division Development Center X-Ray Technology, Würzburg, Germany, 4Siemens Healthcare, Erlangen, Germany, 5Department of Biomedical Engineering, King’s College, London, United Kingdom, 65Department Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Synopsis

Keywords: Pulse Sequence Design, High-Field MRI, fast spin echo, echo train sequence, variable flip angles, sequence optimization, parallel transmit

Motivation: To non-heuristically identify dedicated variable flip angles (VFAs) simultaneously optimized for PSF and/or SNR of multiple tissues in 3D FSE sequences with very long echo trains at 7T.

Goal(s): Flexibly tune between VFAs which favor visibility of small structures (e.g. inner ear imaging), or enhanced signal magnitudes (e.g. low proton-density)

Approach: End-to-end optimization which integrates contrast fidelity, SNR and PSF-penalty to minimize image blurring for multiple tissues.

Results: PSF-optimization yields significantly reduced image blurring compared to standard T2w/FLAIR vendor sequences with pTx and echo train lengths of 220 while maintaining contrast fidelity. SNR-optimization yields strongly increased magnitudes at equal relative SAR.

Impact: This work paves the way to the flexible tuning of the PSF- or SNR-like flavour of dedicated variable flip angles at 7T to enhance visibility of small stuctures or SNR in 3D fast spin-echo sequences with very long echo trains.

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