Keywords: Diagnosis/Prediction, Alzheimer's Disease, Biomarkers, Mild Cognitive Impairment
Motivation: While recent advances in quantitative MRI have resulted in a myriad of methods capable of examining cerebral tissue microstructure, the pre-dementia classification performances of these models have not been extensively studied.
Goal(s): To evaluate diffusion MRI biomarkers as a noninvasive diagnostic tool for early detection of Alzheimer’s disease.
Approach: We utilize multi-shell diffusion MRI from ADNI to investigate the comparative effectiveness of diffusion MRI models (MAP, SMI, NODDI, and C-NODDI) versus established CSF biomarkers in classifying mild cognitive impairment.
Results: Multi-shell diffusion biomarkers match CSF biomarker performance in MCI classification. Greater performance can be achieved when using both MRI and CSF biomarkers simultaneously.
Impact: This research highlights diffusion MRI's potential for classifying prodromal Alzheimer's disease, paving the way for non-invasive pre-dementia diagnostics. It additionally provides MRI researchers insights into the comparative classification performance of various diffusion MRI models.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords