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Abstract #1420

Predictive model for preoperative discerning of tertiary lymphoid structures in gallbladder cancer using Magnetic Resonance Imaging

Weihua Zhi1, Ying Xu1, Sicong Wang2, Lizhi Xie2, Feng Ye1, and Xinming Zhao1
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2GE Healthcare, MR Research, Beijing, China

Synopsis

Keywords: Diagnosis/Prediction, Diagnosis/Prediction, magnetic resonance imaging; radiomics; tertiary lymphoid structure; gallbladder cancer

Motivation: Tertiary lymphoid structures (TLSs) are associated with favorable prognosis and improved response to immunotherapy. However, accurately predicting TLS presence in gallbladder cancer (GBC) preoperatively has remained challenging.

Goal(s): To explore the capability of MRI-based combined model for preoperative prediction of TLS status in GBC, enabling improved prognostic stratification and personalized management.

Approach: Clinical and MRI data from 173 GBC patients were analyzed using a combined MRI-based model to predict TLS status preoperatively.

Results: The MRI-based model demonstrated effective prediction of intratumoral TLS status, aiding in prognostic stratification for GBC patients.

Impact: This MRI-based radiomics predictive model represents an innovative approach to enhance the accuracy of preoperative TLS detection in GBC, potentially facilitating more tailored patient management strategies.

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