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Abstract #1424

Data-Augmented Deep Learning for Tractography Parcellation of Diffusion MRI with Incomplete Field of View

Yuqian Chen1, Leo Zekelman2, Suheyla Cetin-Karayumak1, Yui Lo1, Jon Haitz Legarreta3, Yogesh Rathi1, Nikos Makris1, Fan Zhang4, Weidong Cai5, and Lauren J. O’Donnell1
1Harvard Medical School, Somerville, MA, United States, 2Harvard University, SOMERVILLE, MA, United States, 3Harvard Medical School, SOMERVILLE, MA, United States, 4University of Electronic Science and Technology of China, Chengdu, China, 5The University of Sydney, Sydney, Australia

Synopsis

Keywords: Tractography, Tractography

Motivation: Tractography parcellation is crucial for quantitative analysis of white matter connectivity and microstructure related to brain health and disease. However, real-life dMRI scans often have incomplete Field of View (FOV), and robust tractography parcellation methods do not yet exist.

Goal(s): We aim to propose a robust framework for parcellation of tractograms with inferior FOV cutoff.

Approach: We propose a deep learning framework for effective tractogram parcellation with incomplete FOV by leveraging data augmentation with synthetically cut tractograms.

Results: Evaluations on datasets with simulated and real-world FOV limitations indicate that our method enables effective parcellation of tractography affected by incomplete FOV.

Impact: dMRI scans with incomplete FOV are common in real-life clinical and large-scale research datasets and pose great challenges to identification of anatomical tracts. We propose the first deep learning framework to achieve robust parcellation of tractography affected by incomplete FOV.

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Keywords