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Abstract #1428

Inter-scanner and intra-scanner harmonization of DTI tractography analysis

Ramtilak Gattu1, Vivian Truong1, Yang Xuan1, Fen Bao1, Mya Ismail1, Jiaqi Zhong1, Haamna Minhas1, Ishaan Gattu1, Sagar Buch1, and Yongsheng Chen1
1Neurology, Wayne State university, Detroit, MI, United States

Synopsis

Keywords: Tractography, Diffusion Analysis and Visualization

Motivation: Harmonization of multi-shell 3T DTI is crucial to understand the inter-scan and intra-scan acquisition differences when comparing different DTI and tractography metrics and forms a primary key during data analysis and evaluation.

Goal(s): Evaluating tract based inter-scan and intra-scan differences on multi-shell DTI data acquired on two different scanners

Approach: A multi-shell DTI data was analyzed using tractography based approach and COV and ICC was calculated to study the variability and reproducibility of different DTI metrics.

Results: : COV revealed higher reproducibility from inter-scan acquisition compared to intra-scan acquisition. ICC revealed better consistency with regional analysis compared to tractography analysis between the two scanners.

Impact: This is the first study to compare DTI and tractography metrics between CIMA.X and VERIO visualizing the white matter architecture and connectivity pathways reconstructed by the q-space diffeomorphic reconstruction (QSDR) method using spin distribution function (SDF) in resolving the fibers.

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Keywords