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Abstract #1430

Exploring White Matter Integrity in Leber's Hereditary Optic Neuropathy: Insights from Inferior Longitudinal Fasciculus Tractography

Francesca Punzetti1, Lorenzo Motta2, Virginia Pollarini2, Gianfranco Vornetti2,3, Giovanni Sighinolfi2, Chiara La Morgia2,3, Giulia Amore3, Valerio Carelli2,3, David Neil Manners2,4, Raffaele Lodi2,3, and Caterina Tonon2,3
1Functional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, 2IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, 3Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, 4Department of Life Quality Sciences, University of Bologna, Bologna, Italy

Synopsis

Keywords: Tractography, Diffusion Reconstruction, LHON, DTI, Tractography, Optic Neuropathy, neurodegeneration, microstuctural

Motivation: LHON causes vision loss due to optic nerve degeneration, but the involvement of other WM tracts like the inferior longitudinal fasciculus (ILF) remains understudied. Understanding ILF alterations could provide insight into visual and cognitive changes in LHON.

Goal(s): To identify microstructural differences in the ILF between LHON patients and healthy controls.

Approach: Thirteen LHON patients and 13 matched controls underwent MRI with diffusion-weighted imaging and probabilistic tractography. FA, MD, and RD were evaluated.

Results: The left ILF in LHON patients showed lower FA and higher RD and MD, indicating possible demyelination and axonal changes, while the right ILF remained similar to controls.

Impact: The results provide new insights into ILF changes in LHON, guiding future research into white matter's role in visual symptoms. This enhanced finding could lead to an increase in the knowledge of disease development aimed to targeted therapeutic strategies.

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