Abstract #1434

Shared and distinctive changes of the white matter in generalized anxiety disorder with or without depressive disorder

Huan Zhou^1,2, Hailong Li^1,2, Lingixao Cao^1,2, Shuangwei Chai^1,2, Changjian Qiu³, Qiyong Gong^1,2,4, and Xiaoqi Huang^1,2,4

¹Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, chengdu, China, ²Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, chengdu, China, ³Mental Health Center, West China Hospital of Sichuan University, Sichuan Clinical Medical Research Center for Mental Disorders, chengdu, China, ⁴Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian, China

Synopsis

Keywords: Tractography, White Matter, Generalized anxiety disorder; White matter microstructure; TRACULA

Motivation: The exact profile of white matter (WM) microstructure abnormalities in GAD with and without comorbid major depressive disorder (MDD) remain unclear.

Goal(s): In this study, we aim to investigate the WM tract integrity in patients with GAD with or without MDD using the TRACULA.

Approach: We used the TRACULA to generate 42 fibers. We compared parameters of each fiber between groups and examined the relationship between metrics and clinical symptoms.

Results: Compared to HCs, we find both pure GAD and GAD comorbid with MDD (GAD-MDD) exhibited alteration in SLF, only GAD-MDD showed alteration in the subregion of the corpus callosum.

Impact: This study identified shared and distinctive changes in GAD patients with or without MDD groups. Current study gave a comprehensive characterization of white matter abnormalities among these patients, and highlight TRACULA's value in identifying critical white matter changes.

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