Abstract #1440

PETALUTE fMRI in the mouse brain

Samuel Booth^1,2,3, Sheng Song^1,2,3, Tzu-Wen Winnie Wang^1,2,3, Tzu-Hao Harry Chao^1,2,3, Stephen Sawiak⁴, Uzay Emir^5,6, and Yen-yu Ian Shih^1,2,3

¹Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Center for Animal Magnetic Resonance Imaging, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Department of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom, ⁵Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁶Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: fMRI Acquisition, fMRI Acquisition

Motivation: GRE-BOLD fMRI suffers from artifacts and poor spatial localization of signal. PETALUTE combines ultra short TE contrast and flexible rosette k-space sampling could address these issues.

Goal(s): To evaluate PETALUTE-fMRI contrast in animals in a Bruker 9.4T preclinical scanner.

Approach: A visual stimulation paradigm was used to obtain fMRI t-maps and time courses from petalUTE image volumes. Data were retrospectively reconstructed with variable undersampling factors to evaluate potential for undersampling.

Results: Robust visual stimulation evoked fMRI contrast was observed using PETALUTE in both the first and second echo images. Contrast was present with retrospective reconstruction of 333, 111 and 37 petals.

Impact: We demonstrate robust fMRI contrast using an ultra short TE sequence with rosette spatial encoding (PETALUTE).

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