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Abstract #1452

Independent Components and Functional Connectivity in Resting-State fMRI: A Comparative Study of Primiparous and Nulliparous Subjects.

Chunming Gu1, Yunhong Shu1, Yingli Gao2, Wei Su2, Qianwen Zhang2, Jiaxiang Xin3, Xiaoxia Du4, and Kaihua Zhang2
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2School of Psychology, Shandong Normal University, Jinan, China, 3MR Research Collaboration, Siemens Healthineers Ltd, Shanghai, China, 4Department of Psychology, Center for Exercise and Brain Science, Shanghai University of Sport, Shanghai, China

Synopsis

Keywords: fMRI Analysis, fMRI (resting state)

Motivation: Motherhood causes significant mental and physical changes, yet research on maternal brain function is limited. We aim to address this gap through resting-state fMRI analysis.

Goal(s): Identify differences in brain regions and functional connectivity between primiparous and nulliparous subjects.

Approach: Resting-state fMRI data were analyzed using group-ICA between two groups. A t-test identified significant clusters. ICA-identified region served as the seed to examine functional connectivity differences between groups.

Results: Group-ICA identified regions in cuneal cortex, occipital cortex, and temporal gyrus. Post-hoc seed-based connectivity analysis using right cuneal cortex as the seed showed increased connectivity with temporal gyrus and decreased connectivity with occipital cortex.

Impact: Our study may help fill critical gaps in our understanding of the maternal brain's functional adaptations, enhancing our knowledge of the mental and physical changes that occur on women after childbirth.

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