Abstract #1454

Correlation of abnormal eye movements and functional neuroimaging in Spinocerebellar Ataxia Type 12 patients as compared to healthy control

Pankaj .¹, Achal Kumar Srivastava², Priyanka Bhat¹, Mukesh Kumar¹, S Senthil Kumaran¹, Ajay Garg³, Ramesh Kumar Agarwal⁴, Ashima Nehra⁵, Roopa Rajan², and Deepak Joshi⁶

¹Nuclear Magnetic Resonance (NMR), All India Institute of Medical Sciences, New Delhi, India, ²Neurology, All India Institute of Medical Sciences, New Delhi, India, ³Dept. of Neuroimaging & Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India, ⁴School of Computer & Systems Sciences, Jawaharlal Nehru University, New Delhi, India, ⁵Department of Neuropsychology, All India Institute of Medical Sciences, New Delhi, India, ⁶Centre for Biomedical Engineering, Indian Institute of Technology (IIT), New Delhi, India

Synopsis

Keywords: Functional Connectivity, Brain Connectivity, Spinocerebellar ataxia type 12, Abnormal eye movement, functional magnetic resonance imaging (fMRI).

Motivation: Functional neuroimaging analysis of oculomotor abnormality, specifically of gaze shifts and drift in spinocerebellar ataxia type 12 will help in understanding the dysfunction.

Goal(s): To understand the abnormality in eye movemant based on fMRI analysis.

Approach: Simultaneous task-based fMRI and eye-tracking data were collected with MR-compatible binocular LCD goggles in 40 SCA12 patients and 25 controls. Task and eye movement abnormality was correlated.

Results: SCA12 group significantly alterations were observed in eye movement patterns, including ocular drift and pupil reactivity. Compared with control subjects, SCA12 had significantly greater more function network activation in the reflexive saccadic task.

Impact: Correlation of abnormal eye movements and functional neuroimaging in Spinocerebellar Ataxia Type 12.

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