Keywords: Functional Connectivity, Brain Connectivity
Motivation: Motivation: Tinnitus research often overlooks the interaction between structural and functional brain networks, focusing primarily on single-modality imaging.
Goal(s): Goal: We aimed to investigate the role of structural connectivity and functional connectivity (SC-FC) coupling in the neural mechanisms underlying chronic tinnitus.
Approach: Approach: We compared SC-FC coupling between patients with chronic tinnitus and matched healthy controls using resting-state functional MRI and diffusion tensor imaging data to investigate connectivity differences.
Results: Results: Patients with tinnitus showed altered SC-FC coupling in key auditory and sensory integration regions, with some couplings correlating with tinnitus severity.
Impact: Our findings revealed specific SC-FC coupling alterations in patients with tinnitus, offering potential biomarkers for assessing severity and providing insights into neural mechanisms that could guide future intervention strategies.
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