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Abstract #1463

Abnormal Structural and Functional Connectivity Coupling in Patients With Chronic Tinnitus

Jiapei Xie1,2, Weidong Zhang2, Yan Bai2, Wei Wei2, Kaixin Li3, Mengzhu Wang3, Xianchang Zhang3, and Meiyun Wang1,2,4
1Zhengzhou University People’s Hospital, Zhengzhou, China, 2Henan Provincial People’s Hospital, Zhengzhou, China, 3Siemens Healthineers Ltd, Beijing, China, 4Henan Academy of Science, Zhengzhou, China

Synopsis

Keywords: Functional Connectivity, Brain Connectivity

Motivation: Motivation: Tinnitus research often overlooks the interaction between structural and functional brain networks, focusing primarily on single-modality imaging.

Goal(s): Goal: We aimed to investigate the role of structural connectivity and functional connectivity (SC-FC) coupling in the neural mechanisms underlying chronic tinnitus.

Approach: Approach: We compared SC-FC coupling between patients with chronic tinnitus and matched healthy controls using resting-state functional MRI and diffusion tensor imaging data to investigate connectivity differences.

Results: Results: Patients with tinnitus showed altered SC-FC coupling in key auditory and sensory integration regions, with some couplings correlating with tinnitus severity.

Impact: Our findings revealed specific SC-FC coupling alterations in patients with tinnitus, offering potential biomarkers for assessing severity and providing insights into neural mechanisms that could guide future intervention strategies.

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