Abstract #1465

Reduced GABA concentration in patients with white matter hyperintensities

Xin Wang¹, Caihong Wang¹, Peifang Miao¹, Ying Wei¹, Liangjie Lin², Zhen Li³, Yong Zhang¹, Jingliang Cheng¹, and Cuiping Ren¹

¹Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Clinical and Technical Support, Philips Healthcare, Beijing, China, ³Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Synopsis

Keywords: fMRI Analysis, Brain

Motivation: People with white matter hyperintensities (WMHs) are often perceived as healthy individuals, yet they are at an increased risk for stroke or dementia with the underlying mechanisms poorly understood.

Goal(s): This study aims to investigate potential alterations of γ-aminobutyric acid (GABA) in subjects with WMHs by using J-edited 1H MR spectroscopy (MRS).

Approach: 24 WMHs patients and 20 healthy controls (HCs) were recruited to undergo MRS scan in left centrum semiovale white matter.

Results: Results showed that there was a significant reduction in GABA+ levels in WMHs patients compared with HCs. Besides, significantly higher levels of tCho in subgroup analysis was found.

Impact: This study demonstrated significant reductions of GABA+ levels in centrum semiovale in WMH patients when compared to HCs. Reduced GABA+ concentrations identified in this study may be underlying pathological mechanisms for the concealed cognitive deficits in WMHs patients.

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