Abstract #1467

Functional connectivity alterations associated with COVID-19-related sleep problems: a longitudinal resting-state fMRI study

Haobo Chen¹, Ling Li², Yunkai Sun², Yi Liu², Wei Chen³, Peng Liu¹, Yanhui Liao^1,2, and An Xie¹

¹Department of Radiology, The People's Hospital of Hunan Province（The First Affiliated Hospital of Hunan Normal University）, Changsha, China, ²Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China, ³MR Research Collaboration Team, Siemens Healthineers Ltd., Wuhan, China

Synopsis

Keywords: Functional Connectivity, COVID-19, Sleep problem

Motivation: Quantitative MRI marker can reflect brain parenchyma alterations induced by virus.

Goal(s): To investigate functional connectivity (FC) alterations in subjects with sleep problem before and after COVID-19 and 2-month follow-ups.

Approach: Resting state functional MRI data were collected and analyzed, and correlations of FC and scores of depressions, stress and sleep were carried out.

Results: At baseline, the elevated FC between the left hippocampus and the right superior frontal gyrus was correlated with depression score. Over the follow-up, FC related to emotional regulation, executive function, and memory decreased, while connectivity associated with semantic processing, attention, and audiovisual processing increased.

Impact: This study provides new insight into the changes in brain function associated with sleep problem (SP) after COVID-19, and these changes may partially explain the development of SP.

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