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Abstract #1472

A one-stop tractography solution for tracing short-range association fibers in early developmental brain

Runjia Lin1,2, Ruolin Li1,3, Minhui Ouyang1,4, and Hao Huang1,4
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2School of Software, Dalian University of Technology, Dalian, China, 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Structural Connectivity, Normal development

Motivation: Tracing short-range association fibers (SAFs) in early developmental brains with diffusion-MRI-based tractography is challenging due to smaller brain sizes and less myelination of the white matter (WM) fibers. Few methods can reliably trace SAF in early developmental brain.

Goal(s): To reproducibly trace high-fidelity SAFs in infant brains and delineate the maturation of SAFs.

Approach: We developed a one-stop tractography solution to reproducibly trace SAFs from infants and young adults through a robust Docker-containerized protocol with cutting-edge short-range tractography algorithm.

Results: Heterogeneous SAF clusters in infant and young adult brains were reproducibly reconstructed and their developmental trends were revealed.

Impact: The cutting-edge short-range tractography protocol offers important insights into the superficial WM maturation in the early developmental brain. The one-stop cross-platform tool can be used for broader neuroscientific and clinical discoveries on brain development.

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Keywords