Abstract #1481

Central Executive Network Alterations in End-Stage Renal Disease Patients with Cognitive Decline

Wenqing Li¹, Yongjun Cheng², Di Wang³, Tongqiang Liu³, and Haifeng Shi¹

¹Department of Radiology, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China, ²Philips Healthcare, Shanghai, China, ³Department of Nephrology, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China

Synopsis

Keywords: Structural Connectivity, Brain

Motivation: Cognitive impairment (CI) poses a significant challenge in end-stage renal disease (ESRD), with early detection being particularly difficult.

Goal(s): To investigate central executive network attributes related to subjective cognitive decline (SCD) in ESRD.

Approach: The study examined 43 ESRD patients with mild CI, 37 with SCD, 36 with normal cognition, and 51 healthy controls using MR scanning and graph theory.

Results: σ and Eg metrics were higher in mild CI than controls. Ne was lower in SCD compared to mild CI. σ and Eg were negatively correlated with MoCA scores.

Impact: This study uncovered the neuropathological mechanism behind SCD in patients with ESRD, potentially facilitating ultra-early diagnosis of CI in these patients and guiding early clinical intervention.

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