Abstract #1488

Metabolic and structural white matter integrity in drug-resistant temporal lobe epilepsy: A multimodal study using MRSI and DTI

Haiqing Zhang¹, Bingyang Cai¹, Yibo Zhao², Yudu Li^2,3,4, Wen Jin^2,5, Ya Cui¹, Jiwei Li¹, Miao Zhang⁶, Zhi‑Pei Liang^2,5, and Jie Luo¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States, ³Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁴National Center for Supercomputing Applications, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁵Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁶Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: White Matter, Molecular Imaging

Motivation: How axonal NAA changes in epilepsy and whether it is concordant with DTI metrics remains unclear.

Goal(s): To investigate white matter metabolic and structural integrity using MRSI and DTI.

Approach: Sixty-nine patients with drug-resistant TLE were recruited. WM NAA and fractional anisotropy (FA) were calculated for TLE and compared to healthy controls. Hippocampal NAA was used to predict integrity of its connected fibers.

Results: NAA levels did not correlate with FA in white matter of TLE patients. While hippocampal NAA has direct effect on NAA of CGC and SS, amygdala was found to mediate fornix, SS and CGH.

Impact: This work highlights NAA as an independent marker for white matter metabolic integrity of temporal lobe epilepsy patients in comparison to DTI-FA.

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