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Abstract #1491

Dynamic changes of white matter hyperintensities volume after neoadjuvant chemotherapy in breast cancer patients

Yixin Hu1, Weiwei Lei2, Jiuquan Zhang1, and Ting Yin3
1Department of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China, Chongqing, China, 2Department of Critical Medicine, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China, Chongqing, China, 3MR Research Collaborations, Siemens Healthineers Ltd., Chengdu, China, Chengdu, China

Synopsis

Keywords: White Matter, White Matter, Neoadjuvant chemotherapy, Breast cancer

Motivation: Understanding the neuroimaging changes after chemotherapy is essential for elucidating the mechanism behind chemotherapy-related cognitive impairment.

Goal(s): To compare the dynamic changes in white matter hyperintensities (WMH) volume across different brain regions in breast cancer patients undergoing neoadjuvant chemotherapy (NAC).

Approach: Brain MRI and neuropsychological tests were conducted at three time points during NAC. Healthy controls underwent the same assessments at corresponding time points.

Results: Following NAC, the volume of WMH in centain brain regions of breast cancer patients increased significantly, and mainly occurred after the first cycle of NAC and then remained stable until the completion of NAC.

Impact: Our preliminary findings indicate that the effects of chemotherapy on WMH volume are mainly acute or subacute, highlighting the importance of early intervention for the prevention of chemotherapy-related cognitive impairment.

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