Keywords: White Matter, CEST & MT, Inversion Recovery
Motivation: In vivo lipid quantification in brain tissue is challenging due to limited uniform spin inversion with conventional adiabatic pulses, affecting transient NOE (tNOE) reliability.
Goal(s): Optimize B1 amplitude of hyperbolic secant (HS) adiabatic pulses in tNOE to reduce magnetization transfer (MT) effects and improve lipid quantification repeatability.
Approach: Validated optimized pulse parameters on a water phantom, then acquired repeatable tNOE maps in vivo, assessing white and gray matter contrast.
Results: Optimized scanner voltage (305 V) produced high-quality tNOE contrast with minimal MT interference, showing CoVs of 1% for white and 3% for gray matter.
Impact: This approach may improve lipid degeneration monitoring in neurodegenerative diseases like MS and Alzheimer’s.
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