Meeting Banner
Abstract #1501

Cerebral microbleeds in community-based older adults imaged both in-vivo and ex-vivo: A clinical, MRI and pathology study

Md Tahmid Yasar1, Grant Nikseresht2, Abdur Raquib Ridwan3, Shengwei Zhang3, David A. Bennett3, Julie A. Schneider3, and Konstantinos Arfanakis1,3
1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Computer Science, Illinois Institute of Technology, Chicago, IL, United States, 3Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Synopsis

Keywords: Aging, Neuro, Aging, Brain, Cerebral microbleeds, Cerebral amyloid angiopathy, Cognition,Ex-vivo applications, In-vivo applications,Neuropathology

Motivation: Cerebral microbleeds (CMBs) are studied in research of aging in-vivo or ex-vivo to study associations with amyloid-related imaging abnormalities (ARIA) and neuropathologies. However, a systematic comparison of CMBs imaged in-vivo and ex-vivo has not been conducted.

Goal(s): To compare CMBs imaged in-vivo and ex-vivo in the same older adults.

Approach: Longitudinal clinical evaluation, in-vivo MRI, ex-vivo MRI and detailed neuropathologic evaluation were combined in 37 community-based older adults.

Results: Most CMBs were detected both in-vivo and ex-vivo. Ex-vivo CMB counts were higher than in-vivo with higher antemortem intervals. Participants with cognitive impairment or cerebral amyloid angiopathy have a higher odd of developing CMBs.

Impact: We demonstrated that cerebral microbleeds (CMB) detected in-vivo were also detected ex-vivo. Also, cognitive impairment and cerebral amyloid angiopathy were associated with higher risk of CMB occurrence prior to death in older adults.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords