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Abstract #1504

Maternal Diet Restriction During Pregnancy Leads to Divergent Hippocampal Enlargement Trajectories in Aging Baboon Offspring

Bowen Yang1, Wei Zhang1, Jinqi Li1, Hillary F. Huber2, Carol A. Shively3, Laura A. Cox4, Peter W. Nathanielsz2, and Geoffrey D. Clarke1
1Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2Southwest National Primate Research Center, San Antonio, TX, United States, 3Pathology - Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, United States, 4Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, United States

Synopsis

Keywords: Aging, Quantitative Imaging, Developmental Programming; Neurodegenerative; Prenatal nutrition;Neural development;

Motivation: To study how baboon maternal undernutrition (MUN) during pregnancy impacts hippocampal size and structure in adult offspring across the lifespan.

Goal(s): To evaluate changes to hippocampal volume MUN produces in offspring across the lifespan, due to fetal and post-partum nutritional deficits.

Approach: Longitudinal MRI analysis of hippocampal volume in a baboon model compared MUN offspring and control groups at youth and middle age, assessing structural impacts of prenatal nutritional deficits on aging brains.

Results: MUN was associated with reduced hippocampal volumes, especially in anterior regions, indicating that early MUN may lead to lasting neuroanatomical changes in offspring.

Impact: These findings suggest early-life nutritional deficits can shape brain aging, offering a model to explore interventions that support healthy cognitive aging in individuals with prenatal and post-partum exposure to MUN.

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