Keywords: Aging, Quantitative Imaging, Developmental Programming; Neurodegenerative; Prenatal nutrition;Neural development;
Motivation: To study how baboon maternal undernutrition (MUN) during pregnancy impacts hippocampal size and structure in adult offspring across the lifespan.
Goal(s): To evaluate changes to hippocampal volume MUN produces in offspring across the lifespan, due to fetal and post-partum nutritional deficits.
Approach: Longitudinal MRI analysis of hippocampal volume in a baboon model compared MUN offspring and control groups at youth and middle age, assessing structural impacts of prenatal nutritional deficits on aging brains.
Results: MUN was associated with reduced hippocampal volumes, especially in anterior regions, indicating that early MUN may lead to lasting neuroanatomical changes in offspring.
Impact: These findings suggest early-life nutritional deficits can shape brain aging, offering a model to explore interventions that support healthy cognitive aging in individuals with prenatal and post-partum exposure to MUN.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords