Abstract #1511

Automated Estimation of White Matter Hyperintensity Burden from 2D T2w TSE as an Alternative to 3D FLAIR

Jonathan A. Disselhorst^1,2,3, Vincent Dunet², Gilles Allali⁴, Hagen H. Kitzler⁵, Nicolas Menjot de Champfleur^6,7, Emmanuelle Le Bars^6,7, Veronica Ravano^1,2,3, Tommaso Di Noto^1,2,3, Tom Hilbert^1,2,3, and Bénédicte Maréchal^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ²Department of Medical Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Leenaards Memory Centre, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁵Institute of Diagnostic and Interventional Neuroradiology, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany, ⁶Department of Neuroradiology, Hospital and University of Montpellier, Montpellier, France, ⁷Institut d'Imagerie Fonctionnelle Humaine (I2FH), Hospital and University of Montpellier, Montpellier, France

Synopsis

Keywords: Aging, Segmentation, Neurodegeneration, AI/ML Software, Data Analysis

Motivation: FLAIR imaging is sensitive for detecting white matter hyperintensities (WMHs) but sometimes unavailable due to lengthy acquisition times.

Goal(s): To assess 2D T2w TSE sequences as an alternative to 3D FLAIR for the automated estimation of WMH volumes.

Approach: WMHs were segmented from FLAIR images, and the images were registered to TSE images. Two neural networks were trained for skull stripping and WMH segmentation on TSE images. Separate test sets with paired FLAIR/TSE were used to evaluate the method.

Results: TSE-based segmentation correlated strongly with FLAIR (TIV: 0.98, WMH: 0.95), demonstrating suitability of TSE for estimating total WMH volume.

Impact: Using 2D T2w Turbo Spin Echo (TSE) sequences for white matter hyperintensity (WMH) volume estimation provides a dependable alternative to 3D FLAIR, particularly when quick scan protocols are necessary, but WMH estimation is still needed.

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