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Abstract #1515

Comparative Feasibility of Multimodal Imaging Indicators for Glymphatic Function in Hematological Diseases: Significant Age Effects

Jing Liu1, Yifei Zhang2, Yan Chen1, Wenjia Wang2, Honghai Chen1, Yuhai Cao1, Ying Wang1, Yanan Huang1, Yue Zhao1, Zhijie Kang1, and Dongxue Qin1
1The Second Hospital Of Dalian Medical University, Dalian, China, 2GE Healthcare, MR Research China, Beijing, Bejing, China

Synopsis

Keywords: Biomarkers, biomarkers, Glymphatic system, DTI-ALPS, BOLD-CSF Coupling, Choroid plexus (CP) volume

Motivation: At present, there are many imaging analysis methods to assess cerebral glymphatic function, but the reliability of these methods remains controversial.

Goal(s): This study aims to compare the feasibility of different imaging indicators of glymphatic function in patients with hematological diseases.

Approach: Multimodal neuroimaging (including DTI-ALPS, BOLD-CSF coupling, and choroid plexus volume) and laboratory biomarkers were used to evaluate glymphatic function in patients with hematological diseases.

Results: DTI-ALPS index and choroid plexus (CP) volume were significantly influenced by age, while BOLD-CSF coupling showed minimal correlation with age and a positive correlation with hemoglobin (Hb) levels.

Impact: Imaging methods for evaluating glymphatic function should be selected carefully, with special consideration of age-related influences on DTI-ALPS index and CP volume, particularly when samples involve a wide age range.

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Keywords