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Abstract #1517

MR-guided TOF-BSREM PET Reconstruction on PET/MRI: Improved Inter-Reader Reproducibility and Diagnostic Confidence in Amyloid-beta PET

Munenobu Nogami1,2, Junko Inoue Inukai3, Feibi Zeng3, Matthew G Spangler-Bickell4, Takako Kurimoto5, Kazuhiro Kubo 1, Hidehiko Okazawa2, and Takamichi Murakami1,3
1Department of Radiology, Kobe University Hospital, Kobe, Hyogo, Japan, 2Biomedical Imaging Research Center, University of Fukui, Fukui, Japan, 3Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan, 4GE HealthCare, Waukesha, WI, United States, 5GE HealthCare, Hino, Japan

Synopsis

Keywords: PET/MR, PET/MR

Motivation: With the approval of disease-modifying therapies for Alzheimer’s disease, accurate amyloid-beta PET assessment is crucial to determine their indicattions, requiring reproducibility and repeatability in visual and quantitative evaluations.

Goal(s): To assess the inter-reader reproducibility and quantitative accuracy of amyloid-beta PET imaging using MR-guided TOF-BSREM (MRgTOF-BSREM) compared to TOF-OSEM.

Approach: Amyloid-beta PET images from 22 patients were reconstructed with MRgTOF-BSREM and TOF-OSEM. Three readers visually assessed images, and quantitative measurements of Centiloid scale and SUVR were analyzed for agreement.

Results: MRgTOF-BSREM showed improved inter-reader reproducibility and image quality confidence over TOF-OSEM, with high correlation in quantitative metrics, indicating potential for enhanced diagnostic reliability.

Impact: MRgTOF-BSREM improves inter-reader reproducibility and diagnostic confidence in amyloid-beta PET imaging compared to conventional methods, supporting its potential to enhance treatment indication assessments for Alzheimer’s disease-modifying therapies through more accurate visual and quantitative evaluations.

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Keywords