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Abstract #1522

Multimodal fMRI, Electrophysiological, and Electrochemical Recording Reveal Dopaminergic Modulation of Connectivity Dynamics

Tatiana A Shnitko1, Gabriel Zheng Gong1, Matthew Verber2, Sheng Song2, Minna McFarland2, Rainy Peng2, Tzu-Wen Winnie Wang2, Martin J. MacKinnon2, and Yen-Yu Ian Shih2
1Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Multimodal, Multimodal, fMRI Acquisition; Neuroscience; Small Animals; Psychiatric Disorders

Motivation: Resting-state connectivity in cortico-striatal networks is a key clinical biomarker. Local field potentials and dopamine dynamics shape connectivity, underscoring the need to understand these interactions.

Goal(s): We aimed to test concurrent electrophysiological and electrochemical recordings in rodent brains under high-field magnetic conditions.

Approach: A multimodal ePHYS/eCHEM/fMRI system was developed to record dopamine and LFP dynamics in vivo.

Results: SORDINO-based sequences enabled distortion-free ePHYS/eCHEM recordings, capturing VTA-stimulated dopamine release in the vSTR and DA-induced LFP changes, facilitating exploration of vSTR connectivity with cortical salience network nodes.

Impact: This study demonstrates the development and application of novel translational approach for simultaneously acquiring fMRI, electrophysiological, and electrochemical data in a rodent model. This multimodal recording method is valuable for neuroimaging scientists studying neurochemical origins of hemodynamics and brain networks.

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Keywords