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Abstract #1527

Design, setup and establishment of a brain stimulation system and technique for hybrid 3 T MR-FUS in in vivo rats

Ming-Jye Chen1, Kuan-Hung Cho2, Chia-Ching Pan1, Ezequiel Farrher3, Sheng-Min Huang4, Po-Hsun He1, Hsuan-Han Chiang1, Fabian Küppers3, N. Jon Shah3,5,6,7, Hsin-Yun Chang1, Gin-Shin Chen1,8,9, Li-Wei Kuo1,10, and Chang-Hoon Choi3
1Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 2Department of Electronic Engineering, National United University, Miaoli, Taiwan, 3Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich, Juelich, Germany, 4Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan, 5Institute of Neuroscience and Medicine – 11, Forschungszentrum Juelich, Juelich, Germany, 6Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 7JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany, 8Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan, 9Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung City, Taiwan, 10Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan

Synopsis

Keywords: Multimodal, Multimodal, MR-FUS, MRgFUS

Motivation: Combining non-invasive systems and techniques of MRI and focused ultrasound (FUS), MR-FUS enables access to brain activity.

Goal(s): This study focuses on integrating a hybrid MR-FUS system and refining it for potential neuromodulation applications.

Approach: A custom-designed RF coil and FUS transducer were integrated into a 3 T MRI scanner, and system performance was evaluated by imaging healthy rats.

Results: No artefacts were observed with/without FUS operation. The system’s accuracy and reliability were demonstrated using temperature maps indicating FUS-induced focal regions, T2-weighted images and fractional anisotropy/mean diffusivity maps.

Impact: This integrated MR-FUS system enables non-invasive access to brain activity and its reliability has been demonstrated in healthy rats, with no artefacts during FUS operation, supporting potential advancements in neuromodulation research.

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Abstract

Keywords