Keywords: Diagnosis/Prediction, Diagnosis/Prediction
Motivation: The application of 21-gene assays in clinical practice is jeopardized by the cost and availability.
Goal(s): To identify MRI subregion radiomics signatures associated with the Oncotype Dx 21-gene recurrence score (RS).
Approach: 154 patients were enrolled. Radiomics features were extracted from intratumoral subregions on T2WI and the last phase of post-enhancement (CL) images, which were combined with clininal-imaging features to construct models for distinguishing high (RS ≥ 26) from low (RS < 26) recurrence risk.
Results: The model that combined T2 and CL subregional radiomics features with clinical-imaging characteristics had the highest efficacy, with an AUC of 0.81 for the validation cohort.
Impact: This study first identified radiomics signatures using intratumoral subregional features to predict RS accurately and cost-effectively in ER+/HER2- breast cancer.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords