Keywords: Functional Connectivity, Parkinson's Disease, Parkinson’s Disease Subtypes, Dynamic Functional Connectivity, Temporal Metrics, area under the curve
Motivation: Understanding the neural mechanisms of tremor-dominant (TD) and postural instability/gait difficulty (PIGD) subtypes in Parkinson's disease is essential, however previous studies often overlooked the dynamic fluctuations of functional connectivity (dFC).
Goal(s): This study aims to analyze the differences in dynamic functional connectivity (dFC) temporal features between PD-TD and PD-PIGD patients and evaluate their diagnostic potential.
Approach: The fMRI was performed on 32 PD-TD and 38 PD-PIGD patients. Dynamic functional connectivity (dFC) was analyzed using a sliding-window method and K-means clustering.
Results: Significant differences in dFC metrics were observed, suggesting potential implications for subtype differentiation, however, the diagnostic accuracy remained moderate.
Impact: These findings may inform personalized treatment strategies and promote further inquiries into neural connectivity variations in Parkinson's disease subtypes.
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