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Abstract #1565

Distinct Dynamic Functional Connectivity Patterns in Tremor-Dominant and Gait Disturbance Subtypes of Parkinson’s Disease

Yihang Zhou1, Wei Wei2, Xinhui Wang2, Kaiyue Ding3, Shuo Liu1, Mengzhu Wang4, Kaixin Li4, Xianchang Zhang4, and meiyun wang3
1Department of Radiology, Xinxiang Medical University People's Hospital & Henan Provincial People's Hospital, zhengzhou, China, 2Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, zhenghzou, China, 3Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, zhengzhou, China, 4MR Research Collaboration, Siemens Healthineers Ltd, Bei jing, China

Synopsis

Keywords: Functional Connectivity, Parkinson's Disease, Parkinson’s Disease Subtypes, Dynamic Functional Connectivity, Temporal Metrics, area under the curve

Motivation: Understanding the neural mechanisms of tremor-dominant (TD) and postural instability/gait difficulty (PIGD) subtypes in Parkinson's disease is essential, however previous studies often overlooked the dynamic fluctuations of functional connectivity (dFC).

Goal(s): This study aims to analyze the differences in dynamic functional connectivity (dFC) temporal features between PD-TD and PD-PIGD patients and evaluate their diagnostic potential.

Approach: The fMRI was performed on 32 PD-TD and 38 PD-PIGD patients. Dynamic functional connectivity (dFC) was analyzed using a sliding-window method and K-means clustering.

Results: Significant differences in dFC metrics were observed, suggesting potential implications for subtype differentiation, however, the diagnostic accuracy remained moderate.

Impact: These findings may inform personalized treatment strategies and promote further inquiries into neural connectivity variations in Parkinson's disease subtypes.

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Keywords