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Abstract #1567

Altered large-scale global brain networks in distinct motor subtypes of Parkinson's disease.

Miaoran Guo1, Yueluan Jiang2, and Guoguang Fan3
1The First Affiliated Hospital of China Medical University., Shenyang, China, 2MR Research Collaboration Team, Siemens Healthineers Ltd., Beijing, China, 3The First Hospital of China Medical University., Shenyang, China

Synopsis

Keywords: Functional Connectivity, Neurodegeneration

Motivation: The progression and prognosis of Parkinson's disease (PD) vary with different motor subtypes.

Goal(s): This study investigated neuroimaging manifestations underlying clinical differences across PD motor subtypes by examining changes in the dynamic balance of large-scale resting-state brain networks.

Approach: Resting-state networks were isolated using independent component analysis. We analyzed inter- and intra-network interactions across three groups.

Results: Postural instability and gait difficulty-dominant PD displayed more pronounced disruptions in resting-state brain networks relative to tremor-dominant PD, particularly concerning increased imbalance in higher executive cognitive networks interacting with motor networks, where the salience network plays a key regulatory role.

Impact: These findings clarify neuroimaging differences across PD motor subtypes, potentially reveal early imaging biomarkers, and offer a new perspective to support clinical diagnosis and treatment.

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