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Abstract #1570

Preliminary Analysis of rTMS-iTBS effects on Resting-State Functional Connectivity in Mild Cognitive Impairment: Targeting DLPFC vs. LPC

Daehun Kang1, Kirk M Welker1, Myung-Ho In1, John Huston III1, Maria I Lapid2, and Yunhong Shu1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Psychiatry & Psychology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Task/Intervention Based fMRI, Functional Connectivity, Multi-echo fMRI, repetitive transcranial magnetic stimulation, intermittent theta burst stimulation, mild cognitive impairment

Motivation: Intermittent theta burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC) or left lateral parietal cortex (LPC) is a potential non-invasive treatment for mild cognitive impairment (MCI). However, studies directly comparing the efficacy of these targets are limited.

Goal(s): To investigate how different iTBS targets impact resting-state functional connectivity (RSFC) within the default mode network (DMN) in MCI subjects.

Approach: Multi-echo RSFC was assessed before and after a 10-day iTBS treatment targeting either the DLPFC, LPC, or vertex (sham), using ROI- and seed-based analyses of DMN-RSFC.

Results: iTBS targeting the DLPFC and LPC induced distinct changes in DMN-RSFC.

Impact: Understanding the target-dependent effects of iTBS may help personalize treatment strategies for mild cognitive impairment, potentially leading to optimized cognitive outcomes for patients with neurodegenerative conditions.

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