Abstract #1574

Poorer cerebrovascular reactivity in cognitively intact individuals with APOE4 detected using resting state BOLD-fMRI

Zacharie Potvin-Jutras^1,2,3, Pierre-Luc Tremblay¹, R. Nathan Spreng^4,5,6,7, Sylvia Villeneuve^4,5,6, Christopher J. Steele^3,8,9, Claudine J. Gauthier^1,2,3, and PREVENT-AD Research Group⁶

¹Physics Department, Concordia University, Montreal, QC, Canada, ²Centre Epic and Research Center, Montreal Heart Institute, Montreal, QC, Canada, ³School of Health, Concordia University, Montreal, QC, Canada, ⁴Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, ⁵Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁶McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada, ⁷StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montreal, QC, Canada, ⁸Department of Psychology, Concordia University, Montreal, QC, Canada, ⁹Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Synopsis

Keywords: fMRI Analysis, fMRI (resting state), Cerebrovascular reactivity

Motivation: Cerebrovascular reactivity (CVR) is reduced in apolipoprotein E4 (APOE4) carriers with Alzheimer’s disease (AD), but its association with APOE4 carriers without cognitive impairment is less understood.

Goal(s): This study aimed to investigate the impact of APOE4 status on CVR in individuals with a family history of AD and assess sex differences.

Approach: CVR was measured using resting-state fMRI without respiratory challenges.

Results: Our results revealed significantly lower relative CVR in individuals with APOE4 carriers in the cortical gray matter, temporal gyrus, insula, and cingulate gyrus. Males with APOE4 were found to be especially impacted in temporal areas.

Impact: These findings suggest that individuals without cognitive impairment who carry the APOE4 genotype present lower cerebrovascular reactivity in multiple gray matter regions compared to non-carriers. Cerebrovascular reactivity may be an early biomarker of cerebrovascular dysfunction in individuals with APOE4 alleles.

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