Abstract #1576

Differential Cerebrovascular Reactivity in the Precuneus: A Resting-State fMRI Study of Alzheimer's Disease and Mild Cognitive Impairment

xue tang¹, Luoyu Wang^2,3, Qi Feng², Hanjun Hu^2,4, Qingqing Wen⁵, Yidi Zhu¹, Zhengluan Liao⁶, Zhongxiang Ding², and Xiufang Xu¹

¹School of Medical Imaging, Hangzhou Medical College, Hangzhou, China, ²Department of Radiology, Hangzhou First People’s Hospital, Hangzhou, China, ³School of Biomedical Engineering, Shanghai Tech University, Shanghai, China, ⁴The Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou, China, ⁵MR Research, GE Healthcare, Beijing, China, ⁶Department of Psychiatry, Zhejiang Provincial People’s Hospital/People’s Hospital of Hangzhou Medical College, Hangzhou, China

Synopsis

Keywords: fMRI Analysis, fMRI (resting state), cerebrovascular reactivity

Motivation: The individual cerebral hemodynamics variations and their relationships with cognitive function are not fully understood for Alzheimer's disease (AD) spectrum disorders.

Goal(s): To investigate changes in cerebrovascular reactivity (CVR) obtained by resting-state functional MRI (rs-fMRI) in patients with mild cognitive impairment (MCI) and AD.

Approach: Rs-fMRI, which does not require engagement in a CO₂-realted task, was utilized to assess CVR in patients with MCI and AD.

Results: Significant changes were observed in the CVR of the precuneus (PCU) in patients with MCI and AD. CVR values showed positive correlation with cognitive function impairment.

Impact: Cerebrovascular reactivity (CVR) obtained by rs-fMRI in the precuneus can reflect the cognitive function impairment in patients with MCI and AD, and might be a potential biomarker for assessing cognitive dysfunction.

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