Keywords: fMRI Analysis, fMRI (task based)
Motivation: Understanding relationship of two models, Yablonskiy and Haacke's (YH) linear model and Davis's power law model, for brain oxygenation metabolism.
Goal(s): Develop a new model for quantifying CMRO2 changes without relying on calibration procedures
Approach: Analyzing YH's linear and Davis's power law models suggests brain O₂/CO₂ ratios may remain constant between rest and vasodilation. We explore conditions where this occurs, potentially enabling CMRO2 estimation without calibration.
Results: New model was validated by comparing M parameter and CMRO2 change calculations with the Davis model. We applied the new model to calculate dynamic CMRO2 changes based on BOLD and CBF data from 11 subjects.
Impact: The reconciliation of YH and Davis models enhances our ability to interpret fMRI data and assess brain function accurately. Understanding their relationship is vital for dynamically quantifying brain oxygen metabolism.
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