Abstract #1603

Regional Superficial White Matter Macrostructural and Microstructural Changes Across the Lifespan

Chloe Cho¹, Maxime Chamberland², Elyssa M. McMaster³, Jongyeon Yoon⁴, Nancy R. Newlin⁴, Daniel Moyer⁴, Bennett A. Landman³, and Kurt G. Schilling⁵

¹Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, Netherlands, ³Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, United States, ⁴Department of Computer Science, Vanderbilt University, Nashville, TN, United States, ⁵Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: White Matter, White Matter

Motivation: Superficial white matter (SWM) comprises a majority of total brain white matter. However, there is currently no clear classification for SWM and its changes across the lifespan have been underexplored.

Goal(s): We propose lobe-specific analyses of SWM to characterize how regional SWM macrostructure and microstructure change across the lifespan.

Approach: Leveraging large-scale neuroimaging data (2380 healthy participants, 5-100 years old), we applied advanced quantitative diffusion tractography to track lobe-specific SWM.

Results: There are differential trajectories in SWM macrostructure and microstructure spatially across brain lobes and temporally across the lifespan, with the greatest changes occurring during development.

Impact: This study characterizes typical lobe-specific changes in SWM integrity and structure across the lifespan. The normative trajectories of macrostructural and microstructural properties further lay a foundation for future research to investigate atypical changes in SWM in neurologic disease.

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