Abstract #1614
Ultra-high field cervical spinal cord quantitative MRI: A 7T multi-center study of traveling spines
Virginie Callot1,2, Mohammed Bennasser1, Samira Mchinda1,2, Daniel Papp3, Robert L Barry4,5,6, Laura Beghini7, Alan C Seifert8, Eva Alonso-Ortiz3,9, Julien Cohen-Adad3,9,10,11, Nadine Graedel12, Martina F Callaghan12, Falk Eippert13, Nikolaus Weiskopf14,15,16, Christoph S Aigner17,18, Patrick Freund14,19, Johanna S Vannesjo7, Aurélien Destruel1,2, Hugo Dary1,2, Maxime Guye1,2, and Maryam Seif19
1Centre de Résonance Magnétique Biologique et Médicale (CRMBM-CEMEREM), CNRS/Aix-Marseille University, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3NeuroPoly Lab, Department of Electrical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 4Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 5Harvard Medical School, Boston, MA, United States, 6Harvard-Massachusetts Institute of Technology Health Sciences & Technology, Cambridge, MA, United States, 7Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway, 8Biomedical Engineering and Imaging Institute, Department of Radiology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New-York, NY, United States, 9Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada, 10Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, QC, Canada, 11Mila - Quebec AI Institute, Montreal, QC, Canada, 12Functional Imaging Laboratory, Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 13Research Group Pain Perception, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 14Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Science, Leipzig, Germany, 15Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth System Sciences, Leipzig University, Leipzig, Germany, 16Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, London, United Kingdom, 17Max Planck Research Group MR Physics, Max Planck Institute for Human Development, Berlin, Germany, 18Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 19Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland
Synopsis
Keywords: Spinal Cord, Spinal Cord, Ultra-High Field, 7T, quantitative MRI, multicenter study, repeatability
Motivation: A reliable standardized 7T qMRI protocol for cervical spinal cord (c-SC) is essential for enabling consistent data collection across multiple centers and maximizing the impact of collaborative studies.
Goal(s): To provide reliable multiparametric MRI (qT1,T2*-CSA,DTI) sensitive to microstructural SC tissue for wider use in 7T multicenter studies.
Approach: Three volunteers were scanned across six 7T MR centers equipped with c-SC RF-coils. Repeatability across centers was evaluated.
Results: The protocol was executed successfully in all centers. WM-COV of qT1 and T2*-CSA was <4.6% and <3.7%, respectively. This work represents an important step towards the adoption of 7T SC MRI protocols.
Impact: Our multiparametric qMRI protocol for 7T spinal cord imaging can enable multicenter clinical studies and provide guidance for new investigators, ultimately advancing diagnostic and prognostic capabilities for spinal cord diseases while deepening our understanding of neurodegenerative changes.
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