Keywords: Spinal Cord, Quantitative Imaging, spinal cord, dorsal nerve root lesion
Motivation: We hypothesize that dorsal nerve root injury induces inflammation-associated axonal degeneration in the adjacent regions in intact spinal cord.
Goal(s): Our primary objective is to comprehensively evaluate early-stage regional changes in the cervical spinal cord of non-human primates following a unilateral injury to dorsal nerve root bundles of C4 and C5 segments.
Approach: Diffusion, quantitative magnetization transfer, and chemical exchange saturation transfer MRI provide specific metrics for assessing structural and biochemical changes post-injury.
Results: Results show secondary damage in the adjacent dorsal root entry zone (DREZ) and altered local fiber orientations after dorsal nerve root injury.
Impact: Multi-parametric MRI offers sensitive and specific metrics for assessing changes within the spinal cord after sensory nerve root injury. Our findings reveal the early-stage structural and biochemical alterations at the damaged nerve roots and the adjacent dorsal root entry zone.
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