Abstract #1622

Comparison of Acute In-vivo and Postmortem Ex-vivo MRI Metrics in Spinal Cord Injury

Noah Marini¹, Nikolai Lesack^1,2,3, Sarah Rosemary Morris^1,2,3, Andrew Yung^1,2,4, Kirsten Bale^2,4, Shana George⁵, Andrew Bauman⁴, Piotr Kozlowski^1,2,3,4, Zahra Samadi-Bahrami^1,5, Caron Fournier^1,5, Pushwant Mattu⁶, Lisa Parker⁶, Kevin Dong¹, Femke Streijger¹, Wayne Moore^1,5,6, Adam Velenosi¹, Veronica Hirsch-Reinshagen^1,5,6, Brian Kwon^1,7, and Cornelia Laule^1,2,3,5

¹International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁴UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁵Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Vancouver General Hospital, Vancouver, BC, Canada, ⁷Orthopaedics, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Spinal Cord, Spinal Cord, spinal cord injury, post-mortem, ex-vivo, lesion length, clinical MRI

Motivation: Comparing MRI at time of spinal cord injury (SCI) with post-mortem ex-vivo imaging may help inform if, and how, acute-setting in-vivo clinical MRI can predict long-term tissue damage.

Goal(s): To compare acute in-vivo MRI and postmortem ex-vivo MRI metrics in traumatic SCI.

Approach: Comparisons between in-vivo MRI (lesion length, cord compression, canal compromise) and post-mortem MRI (lesion length, lesion volume, cord damage percentage) in 15 people were assessed using partial correlations and linear regressions.

Results: In-vivo cord compression inversely correlated with injury-to-death interval. Ex-vivo lesion length and volume predicted percentage of core damage at epicenter. Acute and post-mortem MRI metrics were not related.

Impact: Acute in-vivo MRI at time of spinal cord injury may be insufficient to predict the degree of permanent tissue damage. Additional MRI methods are needed to improve spinal cord injury long-term prognostication.

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