Keywords: Spinal Cord, Spinal Cord, Spinal cord injury, Brain, Cervical cord, T1 mapping, MP2RAGE
Motivation: Underlying mechanisms of spinal cord injury (SCI), including structural and myelin changes are understudied. T1 quantification is indirectly sensitive to tissue microstructure along the central nervous system (CNS).
Goal(s): To investigate SCI-induced tissue changes using MP2RAGE T1 quantification above and below the lesion site.
Approach: Quantitative T1 (qT1) values were obtained in 18 SCI and 20 healthy subjects using an optimized MP2RAGE sequence covering both the brain and cervical cord (C1-C7).
Results: SCI showed significantly higher qT1 values in the cervical cord compared to healthy subjects, suggesting myelin alterations remote from the site of injury.
Impact: T1 mapping along the central nervous system enables better understanding anterograde and retrograde degenerative processes in vivo after SCI within scan times appropriate for clinical routine.
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