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Abstract #1624

Simultaneous T1 quantification across brain and entire cervical cord in traumatic spinal cord injury (SCI)

Anna Lebret1, Arash Forodighasemabadi2, Simon Schading-Sassenhausen1, Patrick Freund1,3, Virginie Callot4,5, and Maryam Seif1,3
1Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, 2IHU LIRYC, Univ of Bordeaux, Pessac, France, 3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4CNRS, CRMBM, Aix-Marseille Univ, Marseille, France, 5CEMEREM, APHM, Hopital Universitaire Timone, Marseille, France

Synopsis

Keywords: Spinal Cord, Spinal Cord, Spinal cord injury, Brain, Cervical cord, T1 mapping, MP2RAGE

Motivation: Underlying mechanisms of spinal cord injury (SCI), including structural and myelin changes are understudied. T1 quantification is indirectly sensitive to tissue microstructure along the central nervous system (CNS).

Goal(s): To investigate SCI-induced tissue changes using MP2RAGE T1 quantification above and below the lesion site.

Approach: Quantitative T1 (qT1) values were obtained in 18 SCI and 20 healthy subjects using an optimized MP2RAGE sequence covering both the brain and cervical cord (C1-C7).

Results: SCI showed significantly higher qT1 values in the cervical cord compared to healthy subjects, suggesting myelin alterations remote from the site of injury.

Impact: T1 mapping along the central nervous system enables better understanding anterograde and retrograde degenerative processes in vivo after SCI within scan times appropriate for clinical routine.

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