Meeting Banner
Abstract #1632

Angiopathic Impact of Hypertension and Comorbidities in Healthy Individuals Revealed by Signal Intensity Gradient from TOF-MRA

Chan-Hyuk Lee1, Seul-Ki Jeong2, Hyun Jin Kim3, Robert S. Rosenson4, Wookjin Yang5, and Keun-Hwa Jung5
1Neurology, Ulsan University Hospital, Ulsan, Korea, Republic of, 2Institute for Blood Flow & Metabolism Research, MediIMG, Seongnam, Korea, Republic of, 3Korea Advanced Institute of Science and Technology, Mechanical Engineering, Daejeon, Korea, Republic of, 4Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Neurology, Seoul National University Hospital, Seoul, Korea, Republic of

Synopsis

Keywords: Blood Vessels, Blood vessels, basilar artery, internal carotid artery stenosis, signal intensity gradient, time-of-flight magnetic resonance angiography, wall shear rate

Motivation: Hypertension is a key risk factor, yet its impact on blood flow and wall shear rates (WSR) in intra- and extracranial arteries remains unexamined.

Goal(s): This study examines how hypertension relates to WSR in major intra/extracranial arteries.

Approach: This retrospective study analyzed TOF-MRA-based SIG(signal intensity gradient) to estimate WSR in major arteries, grouping participants by risk factors: no risk, hypertension only, other risks, and hypertension plus additional risks.

Results: In 1,154 subjects, the group of hypertension plus additional risks showed the lowest SIG values in distal ICA, ACA, MCA, PCA, BA, which remained lower after adjusting for confounders, but not in distal ICA.

Impact: Functional analysis using SIG, alongside vascular morphological status, may offer valuable insights into the arterial effects of vascular risk factors, particularly within intracranial cerebral arteries.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords