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Abstract #1638

Improved CBF and BBB Water Exchange Asymmetry in Vascular Territories Following Cranioplasty: A DP-pCASL MRI Study

Brandon Ojogho1, Aidin Abedi1, Darrin J. Lee1, Xingfeng Shao1, Jonathan Russin1, Charles Liu1, and Danny JJ Wang1
1Laboratory of FMRI Technology (LOFT) Mark & Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California (USC), Los Angeles, CA, United States

Synopsis

Keywords: Blood Vessels, Traumatic brain injury, Cerebral Blood Flow

Motivation: Brain injuries often cause cognitive decline, and while cranioplasty has been shown to improve function, the mechanisms are not fully understood. Studying cerebral perfusion changes post-surgery could reveal biomarkers for recovery.

Goal(s): This study investigated changes in cerebral blood flow (CBF), arterial transit time (ATT), and blood-brain barrier (BBB) water exchange rate (Kw) asymmetry in cranioplasty patients.

Approach: Using DP-pCASL MRI, we measured CBF, ATT, kw, and their asymmetries across brain hemispheres in 14 patients before and after cranioplasty.

Results: Significant increases in asymmetry of CBF and kw were observed post-surgery, indicating enhanced blood flow and water exchange in the impacted brain hemisphere.

Impact: This study suggests that cerebral perfusion markers may clarify mechanisms behind cognitive improvements after cranioplasty, potentially guiding future research into biomarkers for brain recovery and influencing clinical approaches to post-injury rehabilitation.

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