Abstract #1640

CVR Transfer Functional Analysis and multi-PLD pCASL MRI to examine vascular dynamics during subacute stroke recovery

Venkatagiri University School of Krishnamurthy^1,2, Lisa Crystal Krishnamurthy^2,3, Peiying Liu⁴, Cuimei Xu⁵, Argye Hillis⁶, and Hanzhang Lu⁵

¹Medicine, Emory University, Atlanta, GA, United States, ²Research Service, Atlanta VAMC, Decatur, GA, United States, ³Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, ⁴Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States, ⁵Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ⁶Neurology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Stroke, Stroke, Cerebrovascular reactivity, multi-delay 3D-pCASL, Transfer function analysis, subacute stroke recovery, vascular dynamics

Motivation: The subacute phase of stroke recovery is crucial for rehabilitation, but the vascular dynamics of repair and angiogenesis remain poorly understood

Goal(s): To examine the capability of physiological MRI to delineate the vascular dynamics during subacute stroke recovery

Approach: CVR transfer function analysis (TFA) and 3D-pCASL (2200 and 2800 msec post-labeling delays) were collected from a subacute stroke patient longitudinally.

Results: The TFA results show that the lesion and surrounding areas stabilize during recovery, with the vascular steal phenomenon occurring in the affected hemisphere. The multi-delay pCASL technique effectively shows a collateral flow that supports recovery and angiogenesis.

Impact: Given that stroke has a vascular etiology, characterizing the vascular remodeling and associated dynamics, especially during the subacute phase is crucial to developing effective stroke rehabilitation strategies. Advanced physiological MRI techniques designed for this purpose can significantly influence clinical practice.

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