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Abstract #1643

Resting state functional MRI with Multi echo GRE EPI on a high performance 0.5 T Head-only Scanner

Arjama Halder1, Sofia Chavez2, Chad T. Harris2, Curtis N. Wiens2, and Andrew T. Curtis2
1Physics, Western University, Mississauga, ON, Canada, 2Synaptive Medical, Toronto, ON, Canada

Synopsis

Keywords: Low-Field MRI, Functional Connectivity, ME GRE EPI, TEDANA, Mid Field

Motivation: Resting state fMRI (rs-fMRI) provides vital neurological information and mid-field scanners offer easier MRI access.

Goal(s): To demonstrate feasibility and reproducibility of rs-fMRI with multi-echo EPI (ME-EPI) acquisition at 0.5 T using a large number of echoes (7) combined with TE-dependent denoising and optimal echo combination.

Approach: We acquire repeated ME-_EPI rs-fMRI acquisitions of eleven healthy volunteers, on 2 consecutive days, at 0.5 T, use ICA to capture networks, and assess reproducibility.

Results: Spatial consistency of correlated regions within a specific network was seen for both individual volunteers and group data. Dice coefficients > 0.5 and ICC ~0.6.

Impact: ME-EPI is feasible for producing reliable rs-fMRI at 0.5 T, potentially expanding access of rs-fMRI in the acute setting.

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Keywords