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Abstract #1659

MR-WAVES: MR simulations from 3D realistic microvascular networks in a few seconds

Thomas Coudert1, Aurélien Delphin2, Maitê Marçal1, Antoine Barrier1, Benjamin Lemasson1, Emmanuel Luc Barbier1, and Thomas Christen1
1Univ. Grenoble Alpes, INSERM U1216, Grenoble Institut Neurosciences, GIN, Grenoble, France, 2Univ. Grenoble Alpes, INSERM US17, CNRS, UAR 3552, CHU Grenoble Alpes, IRMaGe, Grenoble, France

Synopsis

Keywords: Signal Modeling, Simulations, AI, RNN, MRF, MRvF, microvascular, diffusion, microstructure

Motivation: Realistic MR signal simulations incorporating microvascular structures and water-diffusion are crucial to understand fMRI BOLD or DSC experiments and are directly applicable in MRF techniques. Yet, they remain computationally challenging.

Goal(s): To propose a novel simulation tool that efficiently accounts for magnetic susceptibility and water-diffusion effects and can simulate MR-signals from 3D realistic microvasculatures in seconds.

Approach: MR-WAVES combines fast Bloch-simulations, local frequency distributions, and deep neural network water-diffusion predictions. Results were validated against standard microvascular simulations and applied to MRvF estimates in healthy rat brains.

Results: MR signal generation was accelerated nearly 13,000-fold compared to standard simulations, while maintaining MRF reconstruction accuracy.

Impact: We propose a deep learning-based simulation tool for rapid MR signal generation that accounts for microvascular susceptibility and water diffusion effects. This tool could enhance our understanding of the BOLD effect and improve microvascular parameter quantification via MRF methods.

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Keywords