Keywords: Quantitative Imaging, Brain, Polymer
Motivation: Phantoms are tremendously useful for advancing quantitative MRI (qMRI). But anthropomorphic phantoms that truly mimic anatomy and the heterogeneity of relaxation parameters in tissue are still out of reach.
Goal(s): Our work aims to develop reproducible methods for stable control of T1 modulation in UV curable hydrogels without paramagnetic ions that often diffuse without water-tight boundaries.
Approach: We modulate T1 by modifying the polymeric network of our polyacrylamide-polyethylene glycol (pAA-PEGDA) hydrogels,enabling boundaryless T1 contrast between compartments.
Results: Our solution is able to bypass issues of dopant diffusion to create stable, precisely bounded regions of hydrogel with distinct T1 values.
Impact: A reliable, quantitative method for T1 modification in boundaryless hydrogel systems presents a significant opportunity for development in anthropomorphic phantoms. These phantoms have the potential to accelerate the development of quantitative MRI by making research more standardized, reliable, and accessible.
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